HESI Cardiac Safety Committee awards a grant to Nanotools Bioscience to develop next-generation all-optical multiparametric cardiotoxicity assays.

 LA JOLLA, CA – September 3, 2020 – The Health and Environmental Sciences Institute (HESI)

and its Cardiac Safety Committee recently awarded Nanotools Bioscience a 12-month grant to develop next-generation all-optical multiparametric cardiotoxicity assays empowered by novel non-genetic optical pacing technology and deep learning algorithms. This sub-award is a part of a multi-year U01 grant that the HESI Cardiac Safety Committee was awarded by the US FDA for the “Evaluation of Integrated Human-Relevant Approaches to Identify Drug-Induced Cardiovascular Liabilities.” This grant supports HESI in funding and managing novel, in vitro experimental studies to develop targeted mechanistic data to inform drug safety assessment for key cardiac “failure modes.”

“Nanotools Bioscience is honored to receive this award from HESI”, - said Dr. Alex Savtchenko, Chief Executive Officer of Nanotools.

“Our goal is to increase the predictiveness of in vitro cardiotoxicity assays by providing hiPSC-derived cardiomyocytes with environmental cues mirroring the in vivo conditions.  and by performing the multiparametric evaluation of the functional activity of at the single-cell level.  Our combined efforts will ultimately result of streamlined and predictive cardiotoxicity screening as envisioned by the participants of the Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative.  The successful outcome of this project will lead to the accelerated development of less expensive and more efficient drugs."

NCATS awards SBIR Phase I Grant to Nanotools Bioscience to develop the system for enhanced maturation of stem cell-derived cardiomyocytes

La Jolla, CA – July 1, 2020 - Nanotools Bioscience is proud to announce that it received the SBIR Phase I award from the National Center for Advancing Translational Sciences (NCATS) in the amount of $325,000 to develop a cutting-edge bioengineering system that that will optically pace hiPSC-derived cardiomyocytes over extended periods of time to eventually drive their maturation toward the adult phenotype in an activity-dependent manner.

When completed, our innovative and easy-to-use bioengineering system will empower stem cell scientists from the scientific and clinical communities to develop multi-parametric, reproducible, efficient, and individualized protocols for producing adult-like patient-specific hiPSC-derived cardiomyocytes CMs in an accelerate fashion. The proposed project will offer conceptual insights into environmental stimuli needed for enhanced maturation of hiPSC-derived cells and provide a complete set of advanced bioengineering tools to stem cell researchers around the world, leading to accelerated progress in cardiovascular drug discovery and regenerative medicine.   

PhotonMaker Launch 

Nanotools Bioscience launched a 7-wavelength high-power LED light source to enable all-optical assays

La Jolla, CA – June 1, 2020 – To address the need for independent temporal control of several light signals of different wavelengths at once for biomedical and screening applications, Nanotools Bioscience developed and launched a 7-wavelength high-power LED light source.

The system allows controlling the light application patterns via an intuitive GUI interface, adapted for drug discovery screening needs. The advanced triggering system makes this light source fully compatible with different kinds of external devices. 

NHLBI awards R21 research grant to Nanotools Bioscience and George Washington University to develop an optical cardiac pacemaker device.

La Jolla, CA – April 15, 2020 - The National Heart, Lung, and Blood Institute (NHLBI) has awarded a collaborative R21 research grant in the amount of $ 439,819 to Nanotools Bioscience and the team from the George Washington University to develop a revolutionary cardiac pacemaker that is relying on optical rather than electrical stimulation of cardiac tissues. 

This device will be aided by our graphene-mediated optical stimulation (GraMOS) technology that relies on unique optoelectronic properties of graphene to convert light into electricity and induce the changes in the electrical field across the cardiac cell membrane. This technology combined with an implantable wireless miniaturized LED system is expected to lay the foundation for the new generation of cardiac pacemakers.

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